Do I have to configure UART hardware flow control (RTS/CTS) on my Lyra development board first, or is it already enabled by default?

All Lyra development boards are by default in a floating state and use an "auto" configuration for the virtual COM Port (VCOM); therefore, it is highly recommended to do so whenever possible. In this case, please refer here for instructions and more details on how to set up UART hardware flow control (RTS/CTS) properly with your Lyra hardware for evaluation.