Answer
Calculations show that the OTP in the 60-series can be written to well more than 100 times.
That is in contradiction with some apps notes that still state a value of 10 times. That luckily is not true. You can savely consider a number 100 times during your development work.
However, as the term OTP (One-Time-Programmable) memory suggests it will fill up one by one with every change of the regualtory domain and will eventually be full. It will then be stuck with the last regualtory doamin that it has been changed to.
So, it is advised to not change the regulatory as part of your design as the OTP will top up eventually.