LE Audio introduces the concept of Isochronous channels. The higher layers of the protocol are responsible for controlling the timing of the isochronous channels. For example, if using a pair of earbuds there would be two isochronous channels (Isochronous Group) used to transport left and right audio. These two channels must have a tight timing between them to minimize delay of audio heard between the left and right earbud.

Isochronous channels are part of the Bluetooth controller and are used for the transport of audio data. The BT850 and BT860 Bluetooth controllers do not provide isochronous channels support. Therefore, even though the BlueZ host stack now adds LE Audio support it cannot be used with the BT850 or BT860 Bluetooth controllers.

The Cypress CYW20704 A2 chipset, which the BT85x and the BT860 is based on, theoretically supports up to 127 Bluetooth LE connections. However, because the BT860 is an HCI module it is dependent on the Bluetooth stack running on the host therefore, the number of connections will depend on what the host CPU and memory capacity can support.

Additionally, as the number of connections increases, the throughput per each connection will decrease and the processing and memory requirements will increase, which can lead to increased latency. So while 127 is the theoretical limit the actual limit in practical use case would be less than that.

The shelf life statements are essentially to prevent mishandling of the product and not storing it properly. If the modules are still sealed in the package, stored at the proper temperature and have not been exposed to moisture they should be fine. However, when working with modules beyond their shelf life you MUST bake the modules before populating the them to your board. Failure to bake the modules could result in the yield rate dropping down lower than expectation due to popcorn or de-lamination on the modules. It is recommended that you follow IPC/JEDEC J-STD-033 which is the general standard for the handling, packing, shipping and use of moisture/reflow sensitive surface mount devices.

Our main concern is around the castellation/pads which solder the module to the board. It is imperative those pads do not get tarnished, as this would cause soldering issues. Humidity can affect solderability as well, as if there is any excess moisture in the solder on the module, during reflow of the module to the board, steam balls can essentially explode the solder and sometimes result in an open circuit (or possibly a short circuit).

As long as all of the moisture handling and temperature guidelines are being followed you will likely have no issues. It is further recommended that when you do the build with modules that have exceeded their shelf life that you start with a handful to perform a test run and do a final test to make sure all is working as expected. As long as there are no issues with the initial test run we would expect that you will not experience any problems.

The BT850, BT851 and BT860 are Bluetooth 5 qualified modules. However, these modules do not support any Bluetooth 5 features.
Per the Bluetooth SIG FAQ, "there are no mandatory features that must be claimed to use the Bluetooth 5.0 specification. However, manufacturers are required to implement all interoperability improvements and errata applied to Bluetooth 5 in order to comply with the specification".

In order to prevent a low power glitch that can cause EEPROM corruption (no field fix for this state) in the BT850/ BT860, a 0.1uF capacitor should be placed on the nRESET line of the radio if the nRESET line is connected to something externally.
If the nRESET line is to be left NC (not connected) then the capacitor is not needed. 

Bluetooth Low Energy uses Services as opposed to the set of standardized profiles that exists for Classic Bluetooth. While some Bluetooth Low Energy services have been standardized by the Bluetooth SIG, the development of custom services is allowed to meet custom application requirements.
 
Because Bluetooth Low Energy uses a completely different protocol than Classic Bluetooth and supports custom services, Bluetooth Low Energy devices cannot connect to a computer through the typical Bluetooth configuration of a computer. Therefore, connecting to a PC requires writing and running a Bluetooth Low Energy Central Role/Client application to collect the data sent from the Bluetooth Low Energy peripheral modules. Application development for PCs and Mobile devices is outside the scope of our support. Alternatively, a BL654 USB dongle could be used as a BLE Central Role device, to collect the BLE data and pass it to the PC over a COM Port. However, you would still need an application to view and process the data received over that COM Port.
 
We generally recommend customers who are new to Bluetooth Low Energy obtain a copy of Getting Started with Bluetooth Low Energy to help them understand the Bluetooth Low Energy protocol and the GATT table. There are also many resources available online which explain this. 

When Bluetooth Low Energy was first introduced and we launched our BL6xx product line (predecessors to the BL65x series) we produced the BL600 and BL620 smartBASIC Application Walkthrough document, which provides an overview of how Bluetooth Low Energy works and how a GATT table is constructed. 

Yes, the following modules share the same pin layout:

BT800 --> BT850
BT830 --> BT860

There are some No Connect (NC) pins on the BT850/860